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master's thesis
Ekspresija kalbindina-D28k i kalretinina u hipotalamusu St3Gal2, St3Gal3 i St3Gal2/3 mišjih modela
2018. urn:nbn:hr:181:193687
Grgac, Robert
Josip Juraj Strossmayer University of Osijek
Department of biology

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Grgac, R. (2018). Ekspresija kalbindina-D28k i kalretinina u hipotalamusu St3Gal2, St3Gal3 i St3Gal2/3 mišjih modela (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:193687

Grgac, Robert. "Ekspresija kalbindina-D28k i kalretinina u hipotalamusu St3Gal2, St3Gal3 i St3Gal2/3 mišjih modela." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:193687

Grgac, Robert. "Ekspresija kalbindina-D28k i kalretinina u hipotalamusu St3Gal2, St3Gal3 i St3Gal2/3 mišjih modela." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:193687

Grgac, R. (2018). 'Ekspresija kalbindina-D28k i kalretinina u hipotalamusu St3Gal2, St3Gal3 i St3Gal2/3 mišjih modela', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:181:193687

Grgac R. Ekspresija kalbindina-D28k i kalretinina u hipotalamusu St3Gal2, St3Gal3 i St3Gal2/3 mišjih modela [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2018 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:181:193687

R. Grgac, "Ekspresija kalbindina-D28k i kalretinina u hipotalamusu St3Gal2, St3Gal3 i St3Gal2/3 mišjih modela", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:181:193687

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Metadata
TitleEkspresija kalbindina-D28k i kalretinina u hipotalamusu St3Gal2, St3Gal3 i St3Gal2/3 mišjih modela
Title (english)Expression of calbindin-D28k and calretinin in the brain of St3Gal2, St3Gal3 and St3Gal2/3 mice models
AuthorRobert Grgac
MentorSenka Blažetić (mentor)
Committee memberIrena Labak (predsjednik povjerenstva)
Committee memberValentina Pavić (član povjerenstva)
Committee memberSenka Blažetić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2018-10-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Kalbindin-D28k i kalretinin pripadaju skupini kalcij vezujućih proteina koji se koriste kao markeri interneurona, koji su heterogeno izraženi unutar hipotalamusa. Hipotalamus je regija mozga odgovorna za funkcije hranjena i održavanje homeostaze organizma. Budući da miševi izražavaju vidljive fenotipske razlike, cilj ovoga istraživanja bio je utvrditi postoji li statistički značajna razlika u ekspresiji navedenih proteina unutar hipotalamusa koja bi mogla rezultirati poremećajem homeostaze i poremećajem u ishrani. Imunohistokemijskom analizom dokazali smo značajne razlike u ekspresiji kalbindina D28k i kalretinina u mozgu genetski preinačenih mišjih modela St3Gal2, St3Gal3 i St3Gal2/3 u usporedbi s miševima divljega tipa (WT).
Abstract (english)
Calbindin-D28k and calretinin belong to a group of calcium binding proteins commonly used as interneuronal markers, which are heterogeneously expressed within the hypothalamus. The hypothalamus is the region of the brain responsible for the functions of feeding and maintaining homeostasis. Since the observed mice models expressed visible phenotypic differences, the aim of this study was to determine whether there was any significant change in the expression of those proteins within the hypothalamus that could result in homeostatic imbalance and nutritional disorders. Immunohistochemistry analysis peformed in this research shows significant differences in the expression of calbindin-D28k and calretinin in the brains of studied St3Gal2, St3Gal3 and St3Gal2/3 genetically modified mice models when compared to the wild type (WT) mice.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:193687
Study programmeTitle: Master of Science Graduate University Study Programme in Biology; specializations in: Master of Biology
Course: Master of Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra biologije (magistar/magistra biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-12-05 07:24:31