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master's thesis
ANTIBAKTERIJSKA I ANTIOKSIDATIVNA AKTIVNOST DERIVATA RODANINA SINTETIZIRANIH KNOEVENAGELOVOM KONDENZACIJOM U EUTEKTIČKOM OTAPALU KOLIN-KLORID/UREA
2018. urn:nbn:hr:181:838641
Ivkić, Marijana
Josip Juraj Strossmayer University of Osijek
Department of biology

Cite this document

Ivkić, M. (2018). ANTIBAKTERIJSKA I ANTIOKSIDATIVNA AKTIVNOST DERIVATA RODANINA SINTETIZIRANIH KNOEVENAGELOVOM KONDENZACIJOM U EUTEKTIČKOM OTAPALU KOLIN-KLORID/UREA (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:838641

Ivkić, Marijana. "ANTIBAKTERIJSKA I ANTIOKSIDATIVNA AKTIVNOST DERIVATA RODANINA SINTETIZIRANIH KNOEVENAGELOVOM KONDENZACIJOM U EUTEKTIČKOM OTAPALU KOLIN-KLORID/UREA." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:838641

Ivkić, Marijana. "ANTIBAKTERIJSKA I ANTIOKSIDATIVNA AKTIVNOST DERIVATA RODANINA SINTETIZIRANIH KNOEVENAGELOVOM KONDENZACIJOM U EUTEKTIČKOM OTAPALU KOLIN-KLORID/UREA." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:838641

Ivkić, M. (2018). 'ANTIBAKTERIJSKA I ANTIOKSIDATIVNA AKTIVNOST DERIVATA RODANINA SINTETIZIRANIH KNOEVENAGELOVOM KONDENZACIJOM U EUTEKTIČKOM OTAPALU KOLIN-KLORID/UREA', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 10 December 2024, https://urn.nsk.hr/urn:nbn:hr:181:838641

Ivkić M. ANTIBAKTERIJSKA I ANTIOKSIDATIVNA AKTIVNOST DERIVATA RODANINA SINTETIZIRANIH KNOEVENAGELOVOM KONDENZACIJOM U EUTEKTIČKOM OTAPALU KOLIN-KLORID/UREA [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2018 [cited 2024 December 10] Available at: https://urn.nsk.hr/urn:nbn:hr:181:838641

M. Ivkić, "ANTIBAKTERIJSKA I ANTIOKSIDATIVNA AKTIVNOST DERIVATA RODANINA SINTETIZIRANIH KNOEVENAGELOVOM KONDENZACIJOM U EUTEKTIČKOM OTAPALU KOLIN-KLORID/UREA", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:181:838641

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TitleANTIBAKTERIJSKA I ANTIOKSIDATIVNA AKTIVNOST DERIVATA RODANINA SINTETIZIRANIH KNOEVENAGELOVOM KONDENZACIJOM U EUTEKTIČKOM OTAPALU KOLIN-KLORID/UREA
Title (english)ANTIBACTERIAL AND ANTIOXIDATIVE ACTIVITY OF RHODANINE DERIVATES SYNTHESISED BY KNOEVENAGEL CONDENSATION IN DEEP EUTECTIC SOLVENT CHOLINE CHLORIDE/UREA
AuthorMarijana Ivkić
MentorValentina Pavić (mentor)
MentorMaja Molnar (komentor)
Committee memberIrena Labak (predsjednik povjerenstva)
Committee memberValentina Pavić (član povjerenstva)
Committee memberMirna Velki (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2018-11-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Derivati rodanina su heterociklički organski spojevi koji pokazuju širok spektar bioloških aktivnosti. Uzrok tih aktivnosti su mnogostruke mogućnosti strukturalnih modifikacija kako rodanina tako i njegovih derivata. U svrhu optimizacije primjene derivata rodanina u farmaceutskoj industriji istražuju se i sintetski putovi koji udovoljavaju zahtjevima zelene kemije poput biorazgradivosti, ekonomičnosti i netoksičnosti. U ovom radu je sintetizirana serija derivata rodanina mehanizmom Knoevenagelove kondenzacije s različitim aromatskim aldehidima u zelenom, eutektičkom otapalu sastava kolin-klorid/urea. Sintetiziranim spojevima su ispitane in vitro ukupna antioksidativna aktivnost DPPH metodom te in vitro antibakterijska aktivnost metodom razrjeđivanja bujona uz određivanje minimalne inhibitorne koncentracije.
Abstract (english)
Rhodanine derivates are heterocyclic organic compounds which exhibit a wide range of biological activities. The reason behind that is a large number of structural modification possibilities of both rhodanine and its derivates. For the optimization of rhodanine derivates application in the pharmacological industry, synthetic pathways that adhere to the requitrments of green chemistry such as biodegradbility, economics and nontoxicity, are also being investigated. In this paper a series of rhodanine derivates were synthesised by the Knoevenagel condensation mechanism with various aromatic aldehydes in a green, deep eutectic solvent composed of choline chloride and urea. Total antioxidant activity, measured by DPPH method in vitro, and antibacterial activity, measured by broth dilution method with determination of minimum inhibitory concentracion in vitro, were also determined for synthesised compounds.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:838641
Study programmeTitle: Master of Science Graduate University Study Programme in Biology and Chemistry; specializations in: Master Education In Chemistry and Biology
Course: Master Education In Chemistry and Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra edukacije biologije i kemije (magistar/magistra edukacije biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-11-29 10:03:38