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undergraduate thesis
Uloga crijevne mikrobiote u biologiji tumora
2023. urn:nbn:hr:181:913868
Ključec, Hana
Josip Juraj Strossmayer University of Osijek
Department of biology

Cite this document

Ključec, H. (2023). Uloga crijevne mikrobiote u biologiji tumora (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:913868

Ključec, Hana. "Uloga crijevne mikrobiote u biologiji tumora." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2023. https://urn.nsk.hr/urn:nbn:hr:181:913868

Ključec, Hana. "Uloga crijevne mikrobiote u biologiji tumora." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2023. https://urn.nsk.hr/urn:nbn:hr:181:913868

Ključec, H. (2023). 'Uloga crijevne mikrobiote u biologiji tumora', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 15 April 2024, https://urn.nsk.hr/urn:nbn:hr:181:913868

Ključec H. Uloga crijevne mikrobiote u biologiji tumora [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2023 [cited 2024 April 15] Available at: https://urn.nsk.hr/urn:nbn:hr:181:913868

H. Ključec, "Uloga crijevne mikrobiote u biologiji tumora", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:181:913868

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Metadata
TitleUloga crijevne mikrobiote u biologiji tumora
Title (english)The role of intestinal microbiota in tumor biology
AuthorHana Ključec
MentorSenka Blažetić (mentor)
Committee memberSenka Blažetić (predsjednik povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2023-09-12, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Ljudsko je tijelo domaćin velikog broja mikroba, a posebice onih u crijevima. Zbog velike raznolikosti, crijevna mikrobiota se može smatrati i zasebnim organom koji ima ključnu ulogu u očuvanju zdravlja crijeva, a time i općenito zdravlja čovjeka.. Ekološki je prihvatljiva i nepatogena te posjeduje mutualistički odnos sa svojim domaćinom. Svojim metabolitima održava ravnotežu unutar ljudskih crijeva, no nerijetko stvoreni metaboliti ili izmijenjen sastav crijevnog mikrobioma narušava pripadajuću ravnotežu i uzrokuje upalne ili metaboličke bolesti i pojavu tumora. Prema dostupnim informacijama trenutno tumori izazvani mikrobima čine 20% svih tumora u svijetu, a studijama je i potvrđeno da su primjerice, Bacteroides fragilis ili Helicobacter pylori indikatori tumorigeneze. Osim utjecaja na razvojtumora, crijevna mikrobiota posjeduje i terapijski potencijal. Na sličan način, metaboliti ili određeni bakterijski enzimi sudjeluju u imunoterapiji, dok se transplantacijom fekalne mikrobiote te probioticima i prebioticima obnavlja sastav crijevnog mikrobioma, mijenja tumorski mikrookoliš te na kraju suzbija tumorigeneza.
Abstract (english)
The human body hosts a large number of microbes, especially those in the intestines. Due to its great diversity, the intestinal microbiota can also be considered as a separate organ that plays a key role in reflecting human and gut health. It is ecologically acceptable and non-pathogenic and has a mutual relationship with its host. With its metabolites, it maintains the balance within the human intestines, but often the produced metabolites or the altered composition of the intestinal microbiome disrupt the corresponding balance and cause inflammatory or metabolic diseases and the appearance of tumors. Today, it is considered that tumors caused by microbes make up 20% of all tumors in the world, and studies have confirmed that, for example, Bacteroides fragilis or Helicobacter pylori are indicators of tumorigenesis. In addition to causing tumors, the intestinal microbiota also has therapeutic potential. In a similar way, metabolites or certain bacterial enzymes participate in immunotherapy, while transplantation of fecal microbiota, probiotics and prebiotics restores the composition of the intestinal microbiome, changes the tumor microenvironment and ultimately suppresses tumorigenesis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:913868
Study programmeTitle: Undergraduate University Study Programme in Biology (Bachelor of Science)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsClosed access
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Created on2023-11-06 10:30:33