prikaz prve stranice dokumenta Oksidativni stres kao patološki mehanizam oštećenja parvalbuminskih interneurona
Embargo period 2025-10-09
undergraduate thesis
Oksidativni stres kao patološki mehanizam oštećenja parvalbuminskih interneurona
2020. urn:nbn:hr:181:550095
Martinović, Lovro
Josip Juraj Strossmayer University of Osijek
Department of biology

Cite this document

Martinović, L. (2020). Oksidativni stres kao patološki mehanizam oštećenja parvalbuminskih interneurona (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:550095

Martinović, Lovro. "Oksidativni stres kao patološki mehanizam oštećenja parvalbuminskih interneurona." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2020. https://urn.nsk.hr/urn:nbn:hr:181:550095

Martinović, Lovro. "Oksidativni stres kao patološki mehanizam oštećenja parvalbuminskih interneurona." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2020. https://urn.nsk.hr/urn:nbn:hr:181:550095

Martinović, L. (2020). 'Oksidativni stres kao patološki mehanizam oštećenja parvalbuminskih interneurona', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 24 November 2024, https://urn.nsk.hr/urn:nbn:hr:181:550095

Martinović L. Oksidativni stres kao patološki mehanizam oštećenja parvalbuminskih interneurona [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2020 [cited 2024 November 24] Available at: https://urn.nsk.hr/urn:nbn:hr:181:550095

L. Martinović, "Oksidativni stres kao patološki mehanizam oštećenja parvalbuminskih interneurona", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:181:550095

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Metadata
TitleOksidativni stres kao patološki mehanizam oštećenja parvalbuminskih interneurona
Title (english)Oxidative stress as pathological mechanism of parvalbumin interneurons damage
AuthorLovro Martinović
MentorSenka Blažetić (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2020-09-15, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Oksidativno – redukcijski procesi događaju se u svim stanicama u organizmu, a kada se ravnoteža pomakne u smjeru oksidacije govorimo o disbalansu koji dovodi do stanja oksidativnog stresa – patološkog stanja u kojem se nakuplja toliko reaktivnih vrsta da ih naš organizam više ne može efikasno otklanjati Brzoizbijajući parvalbuminski interneuroni posebno su osjetljivi na oksidativni stres u periodu njihova postnatalnog sazrijevanja. Izlaganje NMDA receptora nekompetitivnim antagonistima poput ketamina, koji blokiraju ove receptore, pokreće IL- 6/Nox2 put u kojem se aktivira Nox2 oksidaza, odgovorna za nakupljanje slobodnih radikala i povišenja razine oksidativnog stresa koji ometa razvoj parvalbuminskih interneurona i može dovesti do gubitka istih.
Abstract (english)
Oxidative – reduction processes occur in all cells of the organism but when the balance shifts in the direction of oxidation we have a disbalance which leads to state of oxidative stress – pathological condition in which so many reactive speaces are accumulated that our body can no longer effectively eliminate it. Fast-spiking parvalbumin interneurons are particularly sensitive to oxidative stress in period of their postnatal maturation. Exposure of NMDA receptors to noncompetitive antaginists such as ketamine, which block these receptors, triggers IL-6/Nox2 pathway in which the Nox2 oxidaze is acivated which is responsoable for accumulation of free radicals and invoking oxidative stress that interferes the development of parvalbumin interneurons and it can lead to thair loss.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:550095
Study programmeTitle: Undergraduate University Study Programme in Biology (Bachelor of Science)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-10-09
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Created on2020-10-09 09:44:52