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undergraduate thesis
Telomere i tumori
2018. urn:nbn:hr:181:242798
Kiralj, Zoran
Josip Juraj Strossmayer University of Osijek
Department of biology

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Kiralj, Z. (2018). Telomere i tumori (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:242798

Kiralj, Zoran. "Telomere i tumori." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:242798

Kiralj, Zoran. "Telomere i tumori." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:242798

Kiralj, Z. (2018). 'Telomere i tumori', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 25 December 2024, https://urn.nsk.hr/urn:nbn:hr:181:242798

Kiralj Z. Telomere i tumori [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2018 [cited 2024 December 25] Available at: https://urn.nsk.hr/urn:nbn:hr:181:242798

Z. Kiralj, "Telomere i tumori", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:181:242798

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Metadata
TitleTelomere i tumori
Title (english)TELOMERES AND TUMORS
AuthorZoran Kiralj
MentorIvna Štolfa Čamagajevac (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2018-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Telomere su terminalne strukture linearnih kromosoma u eukariota koji sadrže ponavljajuću sekvencu. Njihova glavna funkcija je zaštita i pružanje stabilnosti kromosomskim krajevima. U većini humanih somatskih stanica sa svakom staničnom diobom, kromosomi kontinuirano postaju kraći i stanica ulazi u proces staničnog starenja. Suprotno tomu, u tumorskim stanicama aktivan je ribonukleoproteinski enzim telomeraza koji produžuje telomere i omogućuje im daljnju proliferaciju. Kod velikog broja tumora kao što su tumor dojke, tumor pluća, neuroblastom i melanom, telomeraza je eksprimirana u gotovo 85% tumorskih stanica, stoga je glavni cilj antitumorskih terapija upravo njena inhibicija. Do sada su razvijene razne metode za supresiju telomerazne aktivnosti, ali postoji potreba daljnjeg razvoja ovih antitumorskih terapija.
Abstract (english)
Telomeres are terminal structures of linear chromosomes in eukaryotes that contain a repetitive sequence. Their main function is to protect and provide stability to chromosome end regions. In most human somatic cells with each cell division, chromosomes continuosly become shorter and cells enter the cellular aging process. In contrast, tumor cells have active ribonucleoprotein enzyme telomerase which prolongs telomeres and allows them further proliferation. Enzyme telomerase is expressed in almost 85% of tumors (breast tumors, lung tumors, neuroblastoma and melanoma), so the main goal of the anticancer treatment is in its inhibition. So far, various methods have been developed to suppress telomerase activity, but there is a need for further development of these anticancer therapies.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:242798
Study programmeTitle: Undergraduate University Study Programme in Biology (Bachelor of Science)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-02-06 10:05:54