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undergraduate thesis
Uloga IкB kinaznog kompleksa kod Huntingtonove bolesti
2018. urn:nbn:hr:181:797081
Vuković, Nikolina
Josip Juraj Strossmayer University of Osijek
Department of biology

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Vuković, N. (2018). Uloga IкB kinaznog kompleksa kod Huntingtonove bolesti (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:797081

Vuković, Nikolina. "Uloga IкB kinaznog kompleksa kod Huntingtonove bolesti." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:797081

Vuković, Nikolina. "Uloga IкB kinaznog kompleksa kod Huntingtonove bolesti." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:797081

Vuković, N. (2018). 'Uloga IкB kinaznog kompleksa kod Huntingtonove bolesti', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 14 November 2024, https://urn.nsk.hr/urn:nbn:hr:181:797081

Vuković N. Uloga IкB kinaznog kompleksa kod Huntingtonove bolesti [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2018 [cited 2024 November 14] Available at: https://urn.nsk.hr/urn:nbn:hr:181:797081

N. Vuković, "Uloga IкB kinaznog kompleksa kod Huntingtonove bolesti", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:181:797081

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Metadata
TitleUloga IкB kinaznog kompleksa kod Huntingtonove bolesti
Title (english)The role of IкB kinase complex at Huntington's disease
AuthorNikolina Vuković
MentorSenka Blažetić (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2018-09-07, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Huntingtonova bolest jedna je od poznatijih nasljednih bolesti živčanog sustava. Karakteriziraju je simptomi kao što su nekontrolirani motorni pokreti te postepeno kognitivno propadanje koji uglavnom nastupaju u srednjoj životnoj dobi. Mutacija DNA uzrokovana višestrukim ponavljanjem tripleta dušičnih baza CAG uzrok je oboljenja. Dijagnoza bolesti postavlja se genetičkim testiranjem, a liječenje se zasad temelji na ublažavanju simptoma. Iako su biokemijski putevi bolesti višestruko istraženi, stručnjaci još uvijek dolaze do novih spoznaja o pojedinim regulatornim molekulama. IкB kompleks je složena proteinska struktura, a po funkciji enzim građen od tri podjedinice. U organizmu je sveprisutan no u neuronima CNS kod HB pacijenata ključan je u signalnim putevima bolesti. IкBβ podjedinica kompleksa važna je u procesu imunološkog odgovora, a kod Huntingtonove bolesti inhibicija ili stimulacija aktivnosti IкBβ direktno utječe na razvoj simptoma pa i napredak same bolesti.
Abstract (english)
Huntington's disease represents a well known hereditary disorder of nervous system. It is characterized by symptoms such as uncontrolled motor movements and gradual cognitive decay that generally occur in middle age. Cause of the disease is mutation that happens as a result of multiple repeated CAG nitrogen bases. Diagnosis is set by genetic testing, and treatment is based on the relief of the symptoms. Although the biochemical pathways of the disease have been researched, experts are still coming up with new findings about some regulatory molecules. The IкB complex is a compounded protein structure of three subunits, with the function of an enzyme. In organism is ubiquitous, but in CNS neurons of HB patients is crucial in signal pathways of the disease. The IкBβ subunit of complex is important in the immune response processes and at Huntington's disease, inhibition or stimulation of IкBβ activity directly affects the development of symptoms and progression of the illness.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:797081
Study programmeTitle: Undergraduate University Study Programme in Biology (Bachelor of Science)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-12-11 11:39:42