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undergraduate thesis
Ubikvitinacija
2018. urn:nbn:hr:181:137984
Košić, Kristina
Josip Juraj Strossmayer University of Osijek
Department of biology

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Košić, K. (2018). Ubikvitinacija (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:137984

Košić, Kristina. "Ubikvitinacija." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:137984

Košić, Kristina. "Ubikvitinacija." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2018. https://urn.nsk.hr/urn:nbn:hr:181:137984

Košić, K. (2018). 'Ubikvitinacija', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:181:137984

Košić K. Ubikvitinacija [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2018 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:181:137984

K. Košić, "Ubikvitinacija", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:181:137984

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Metadata
TitleUbikvitinacija
Title (english)UBIQUITINATION
AuthorKristina Košić
MentorIvna Štolfa Čamagajevac (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2018-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Ubikvitinacija je glavni put selektivne razgradnje proteina u eukariotskim stanicama. Regulira širok raspon staničnih procesa, uključujući endocitozu, popravak DNA, degradaciju proteina, stanični ciklus i sl. Ključnu ulogu u tom posttranslacijskom mehanizmu imaju proteini ubikvitin (Ub) i proteasom, uz enzime E1, E2 i E3. Ubikvitin je poput biljega koji obilježava proteine određene za uništenje, a proteasom je sam egzekutor. Ukoliko dođe do poremećaja u radu ubikvitin-proteasom sustava (UPS) stanica je u nemogućnosti normalno funkcionirati te se javljaju bolesti. Tumori, autoimunost, neurodegenerativne bolesti, samo su neke od mogućih posljedica u radu UPS-a. Isto tako, različite vrste patogena imaju sposobnost manipulacije domaćinskim ubikvitinacijskim sustavom, što im omogućuje proliferaciju, stoga je važno razumjeti sam molekularni mehanizam kako bismo razvili nove antibakterijske i antitumorske strategije.
Abstract (english)
Ubiquitination is the main mechanism of selective protein degradation in eukaryotic cells. It regulates a wide range of cellular processes, including endocytosis, DNA repair, protein degradation, cell cycle and similar. Main role in this posttranslation mechanism have proteins ubiquitin (Ub) and proteasome, with enzymes E1, E2 and E3. Ubiquitin marks proteins for degradation, while proteasom is the main executor. If a failure in ubiquitin-proteasom system (UPS) occurs, cell doesn't function normally and diseases may show. Tumors, autoimmunity, neurodegenerative diseases are just some of the possible outcomes. Also, various pathogens have ability to manipulate host ubiquitination system, allowing them to proliferate. Hence, it is important to understand molecular mechanism of ubiquitination, so new antibacterial and antitumor strategies can be developed
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:137984
Study programmeTitle: Undergraduate University Study Programme in Biology (Bachelor of Science)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-12-11 11:29:49