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undergraduate thesis
Telomere-starenje i rak
2016. urn:nbn:hr:181:722583
Galić, Emerik
Josip Juraj Strossmayer University of Osijek
Department of biology

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Galić, E. (2016). Telomere-starenje i rak (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:722583

Galić, Emerik. "Telomere-starenje i rak." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2016. https://urn.nsk.hr/urn:nbn:hr:181:722583

Galić, Emerik. "Telomere-starenje i rak." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2016. https://urn.nsk.hr/urn:nbn:hr:181:722583

Galić, E. (2016). 'Telomere-starenje i rak', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:181:722583

Galić E. Telomere-starenje i rak [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2016 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:181:722583

E. Galić, "Telomere-starenje i rak", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:181:722583

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Metadata
TitleTelomere-starenje i rak
Title (english)Telomeres in cancer and aging
AuthorEmerik Galić
MentorIvna Štolfa Čamagajevac (mentor)
Committee memberIvna Štolfa Čamagajevac (predsjednik povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2016-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Telomere su jedinstvene strukture na krajevima kromosoma potrebne za genetsku stabilnost stanice. Pri replikaciji stanične DNA dolazi do skraćivanja telomera zbog uklanjanja zadnje početnice na tromom lancu i nemogućnosti polimerizacije "de novo" krajeva kromosoma pomoću DNA polimeraze. Za spriječavanje kritičnog gubitka telomera, odgovoranje enzim telomeraza. Telomere i telomeraza su važne u biologiji tumora i starenja. Mjerenje aktivnosti telomeraze se koristi u dijagnostici tumora, dok se njena inhibicija pokazala kao nova metoda u liječenju tumora. Skraćivanjem telomera u normalnih stanica dolazi do senescencije. Eksprimiranjem telomeraze je moguće produljiti telomere te produžiti životni vijek stanice. Modernim istraživanjima se pokušava isto postići na razini cijelog organizma.
Abstract (english)
Telomeres are unique structures at the ends of the chromosomes crucial for genetic stability of the cell. Telomeres shorten in the process of DNA replication due to inability of the DNA polymerase to synthesise DNA chain "de novo". Telomere synthesizing enzyme is called telomerase. Telomeres and telomerase are important in cancer biology and aging. Telomerase activity measurement can be used in cancer diagnosis. Telomerase inhibition canbe effective method in cancer therapy. Telomere shortening in normal cells leads to senescence. Telomerase expression can lead to telomere elongation, which in term can lead to extended lifespan. Recent investigations aim to achieve these characteristics on the entire organism scale.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:722583
Study programmeTitle: Undergraduate University Study Programme in Biology (Bachelor of Science)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-01-31 08:57:27