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master's thesis
Povezanost polimorfizama osteoprotegerin gena i nastanka osteoporoze kod postmenopauzalnih žena
2013. urn:nbn:hr:181:713849
Kuna, Lucija
Josip Juraj Strossmayer University of Osijek
Department of biology

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Kuna, L. (2013). Povezanost polimorfizama osteoprotegerin gena i nastanka osteoporoze kod postmenopauzalnih žena (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:713849

Kuna, Lucija. "Povezanost polimorfizama osteoprotegerin gena i nastanka osteoporoze kod postmenopauzalnih žena." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2013. https://urn.nsk.hr/urn:nbn:hr:181:713849

Kuna, Lucija. "Povezanost polimorfizama osteoprotegerin gena i nastanka osteoporoze kod postmenopauzalnih žena." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2013. https://urn.nsk.hr/urn:nbn:hr:181:713849

Kuna, L. (2013). 'Povezanost polimorfizama osteoprotegerin gena i nastanka osteoporoze kod postmenopauzalnih žena', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:181:713849

Kuna L. Povezanost polimorfizama osteoprotegerin gena i nastanka osteoporoze kod postmenopauzalnih žena [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2013 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:181:713849

L. Kuna, "Povezanost polimorfizama osteoprotegerin gena i nastanka osteoporoze kod postmenopauzalnih žena", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:181:713849

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Metadata
TitlePovezanost polimorfizama osteoprotegerin gena i nastanka osteoporoze kod postmenopauzalnih žena
Title (english)Association of osteoprotegerin gene polymorphisms and osteoporosis inpostmenopausal women
AuthorLucija Kuna
MentorElizabeta Has Schon (mentor)
MentorMartina Smolić (mentor)
MBZ: 292155
Committee memberElizabeta Has Schon (predsjednik povjerenstva)
Committee memberMarija Heffer (član povjerenstva)
Committee memberMartina Smolić (član povjerenstva)
MBZ: 292155
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2013-10-24, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Osteoporoza je česta bolest uslijed koje dolazi do smanjenja koštane mase. Nedostatak u mikroarhitekturi koštanog tkiva negativno utječe na čvrstoću kostiju te dovodi do povećanog rizika od prijeloma kostiju. Osteoprotegerin gen (OPG) vrlo je bitan u genetičkoj kontroli koštane mase te ima vrlo značajnu ulogu u nastanku osteoporoze. Najčešći tip polimorfizma pripada SNP polimorfizmu. Otkriće receptora aktivatora nuklearnog faktora kb (RANK)/RANK ligand RANKL/OPG pridonio je boljem razumijevanju načina regulacije formacije i resorpcije kosti.RANK-RANKL-OPG sustav mogao bi biti usmjeren kao nova strategija liječenja bolesti.
Abstract (english)
Osteoporosis is a common disease characterized by low bone mass. Reduced microarchitecture of bone tissues affects bone strength leading to an increased risk of bone fractures .Osteoprotegerin gene (OPG) is an important candidate gene of osteoporosis and may have an important role in development of osteoporosis. SNP polymorphism is the most common type of polymorphism. Discovery of the receptor activator of nuclear factor RANK/RANK ligand RANKL/OPG contributed to understanding of bone formation and resorption. Targeting of RANK- RANKL-OPG system may represent a new strategy in the treatment of bone diseases.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:713849
Study programmeTitle: Master of Science Graduate University Study Programme in Biology; specializations in: Master of Biology
Course: Master of Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra biologije (magistar/magistra biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-01-25 11:25:55