prikaz prve stranice dokumenta Zelena sinteza derivata kinazolinona s potencijalnom antibakterijskom aktivnosti
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master's thesis
Zelena sinteza derivata kinazolinona s potencijalnom antibakterijskom aktivnosti
2022. urn:nbn:hr:181:673652
Prašnikar, Fran
Josip Juraj Strossmayer University of Osijek
Department of biology

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Prašnikar, F. (2022). Zelena sinteza derivata kinazolinona s potencijalnom antibakterijskom aktivnosti (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:673652

Prašnikar, Fran. "Zelena sinteza derivata kinazolinona s potencijalnom antibakterijskom aktivnosti." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2022. https://urn.nsk.hr/urn:nbn:hr:181:673652

Prašnikar, Fran. "Zelena sinteza derivata kinazolinona s potencijalnom antibakterijskom aktivnosti." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2022. https://urn.nsk.hr/urn:nbn:hr:181:673652

Prašnikar, F. (2022). 'Zelena sinteza derivata kinazolinona s potencijalnom antibakterijskom aktivnosti', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:181:673652

Prašnikar F. Zelena sinteza derivata kinazolinona s potencijalnom antibakterijskom aktivnosti [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2022 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:181:673652

F. Prašnikar, "Zelena sinteza derivata kinazolinona s potencijalnom antibakterijskom aktivnosti", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:181:673652

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Metadata
TitleZelena sinteza derivata kinazolinona s potencijalnom antibakterijskom aktivnosti
Title (english)Green synthesis of quinazolinone derivatives with potential antibacterial activity
AuthorFran Prašnikar
MentorMaja Molnar (mentor)
MentorValentina Pavić (komentor)
Committee memberValentina Pavić (predsjednik povjerenstva)
Committee memberMirna Velki (član povjerenstva)
Committee memberElvira Kovač-Andrić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2022-10-11, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Derivati kinazolinona su heterociklički spojevi koji su u fokusu istraţivanja moderne medicine i kemije već nekoliko desetljeća. Konvencionalne laboratorijske sinteze ovih spojeva, koje uključuju različita organska otapala i katalizatore, često štetne za okoliš i samog čovjeka, te se stoga teţi pronalasku novih okolišno prihvatljivih zelenih metoda priprave. Cilj ovoga diplomskoga rada bio je sintetizirati različite derivate kinazolinona iz supstituiranih antranilnih kiselina, anilina i trimetilortoformijata s naglaskom na zeleni pristup. Zelene sinteze su uključivale reakcije potpomognute ultrazvučnim zračenjem, mikrovalnim zračenjem te mehanokemijsku sintezu, uz upotrebu eutektičkih otapala. Eutektička otapala pripravljana su na bazi kolin-klorida i različitih amida, karboksilnih kiselina, alkohola i ugljikohidrata u različitom molarnom omjeru. Prije svake sinteze provedena je optimizacija na modelnoj reakciji kako bi se našlo najprikladnije eutektičko otapalo, temperatura i vrijeme reakcije. Budući da kinazolinoni posjeduju antibakterijsko djelovanje, provedeno je i antibakterijsko ispitivanje.
Abstract (english)
Quinazolinone derivatives are heterocyclic compounds that have been the focus of research in modern medicine and chemistry for several decades. Conventional laboratory syntheses of these compounds, which include various organic solvents and catalysts, are often harmful to the environment and to humans, and therefore efforts are being made to find new environmentally friendly green preparation methods. The aim of this thesis was to synthesize different quinazolinone derivatives from substituted anthranilic acids, aniline and trimethylorthoformate with an emphasis on a green approach. Green syntheses included reactions assisted by ultrasound radiation, microwave radiation, and mechanochemical synthesis, with the use of eutectic solvents. Eutectic solvents were prepared on the basis of choline chloride and different amides, carboxylic acids, alcohols and carbohydrates in different molar ratios. Before each synthesis, optimization was carried out on the model reaction in order to find the most suitable eutectic solvent, temperature and reaction time. Since quinazolinones have an antibacterial effect, an antibacterial test was also carried out.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:673652
Study programmeTitle: Master of Science Graduate University Study Programme in Biology and Chemistry; specializations in: Master Education In Chemistry and Biology
Course: Master Education In Chemistry and Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra edukacije biologije i kemije (magistar/magistra edukacije biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsClosed access
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Created on2022-11-02 10:34:38