prikaz prve stranice dokumenta Primjena zebrice (Danio rerio) za istraživanje učinaka endokrinih disraptora
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undergraduate thesis
Primjena zebrice (Danio rerio) za istraživanje učinaka endokrinih disraptora
2021. urn:nbn:hr:181:468997
Zečević, Nina
Josip Juraj Strossmayer University of Osijek
Department of biology

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Zečević, N. (2021). Primjena zebrice (Danio rerio) za istraživanje učinaka endokrinih disraptora (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:468997

Zečević, Nina. "Primjena zebrice (Danio rerio) za istraživanje učinaka endokrinih disraptora." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2021. https://urn.nsk.hr/urn:nbn:hr:181:468997

Zečević, Nina. "Primjena zebrice (Danio rerio) za istraživanje učinaka endokrinih disraptora." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2021. https://urn.nsk.hr/urn:nbn:hr:181:468997

Zečević, N. (2021). 'Primjena zebrice (Danio rerio) za istraživanje učinaka endokrinih disraptora', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 16 November 2024, https://urn.nsk.hr/urn:nbn:hr:181:468997

Zečević N. Primjena zebrice (Danio rerio) za istraživanje učinaka endokrinih disraptora [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2021 [cited 2024 November 16] Available at: https://urn.nsk.hr/urn:nbn:hr:181:468997

N. Zečević, "Primjena zebrice (Danio rerio) za istraživanje učinaka endokrinih disraptora", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:181:468997

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Metadata
TitlePrimjena zebrice (Danio rerio) za istraživanje učinaka endokrinih disraptora
Title (english)Application of zebrafish (Danio rerio) in assessment of endocrine disruptors effects
AuthorNina Zečević
MentorMirna Velki (mentor)
Committee memberMirna Velki (predsjednik povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2021-06-15, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Endokrini disraptori su prirodni i sintetički spojevi koji negativno utječu na hormonalni sustav životinja oponašajući prirodne hormone u tijelu i narušavajući njihov sadržaj i koncentraciju u organizmu. U okoliš dospijevaju putem podzemnih i površinskih voda, a neki od najčešće korištenih endokrinih disraptora u ovakvim istraživanjima sastavni su dio proizvoda za ljudsku upotrebu. Nalaze se u pesticidima, fungicidima, insekticidima ili plastifikatorima. Kao modelni organizam za istraživanje učinaka endokrinih disraptora koristi se mala tropska akvarijska ribica zebrica (Danio rerio). Istraživanja pokazuju kako endokrini disraptori utječu na spolni, hormonalni, osjetilni i živčani sustav te na ponašanje jedinki zebrice. Ovakvi spojevi uzrokuju deformacije u razvitku spolnih žlijezda zebrice te promjenu spolova. Također, djeluju na tiroidnu žlijezdu što dovodi do negativnih posljedica u pravilnome rastu i razvitku ličinki zebrice. Endokrini disraptori utječu i na stanice bočne pruge zebrice te brojne neurotransmitere i enzime središnjeg živčanog sustava. Osim toga, uzrokuju pojavu anksioznosti i straha u jedinkama zebrice. Kako je genom zebrice vrlo sličan ljudskom genomu, ovakva bi istraživanja mogla poslužiti kao alat za otkrivanje učinaka endokrinih disraptora na čovjeka.
Abstract (english)
Endocrine disruptors are natural and synthetic compounds that negatively affect hormonal system of the animals. They mimic the natural hormones in the body and disrupt their content and concentration. They enter aquatic ecosystems through groundwater and surface water. Some of the most commonly used endocrine disruptors in such researches are an integral part of products for human use. They are found in pesticides, fungicides, insecticides or plasticizers. A small tropical aquarium species zebrafish (Danio rerio) is used as a model organism to investigate the effects of endocrine disruptors. Research shows how endocrine disruptors affect the sexual, hormonal, sensory and nervous systems and also the behavior of zebrafish individuals. Such compounds cause gender reassignment and deformities in the development of the gonads in zebrafish larvae. They also have impact on the thyroid gland leading to negative consequences in the proper growth and development of individuals. Endocrine disruptors also affect zebrafish lateral line cells, enzymes and neurotransmitters which are part of the central nervous system. In addition, they cause anxiety and fear in zebrafish. As the genome of the zebrafish is very similar to the human genome, such research could serve as a tool to detect the effect of endocrine disruptors on humans.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:468997
Study programmeTitle: Undergraduate University Study Programme in Biology (Bachelor of Science)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
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File originBorn digital
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Created on2022-04-11 11:45:05