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undergraduate thesis
Uloga gangliozida u mehanizmu inzulinske rezistencije
2017. urn:nbn:hr:181:546012
Bukulin, Dolores
Josip Juraj Strossmayer University of Osijek
Department of biology

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Bukulin, D. (2017). Uloga gangliozida u mehanizmu inzulinske rezistencije (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:181:546012

Bukulin, Dolores. "Uloga gangliozida u mehanizmu inzulinske rezistencije." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2017. https://urn.nsk.hr/urn:nbn:hr:181:546012

Bukulin, Dolores. "Uloga gangliozida u mehanizmu inzulinske rezistencije." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, 2017. https://urn.nsk.hr/urn:nbn:hr:181:546012

Bukulin, D. (2017). 'Uloga gangliozida u mehanizmu inzulinske rezistencije', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:181:546012

Bukulin D. Uloga gangliozida u mehanizmu inzulinske rezistencije [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of biology; 2017 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:181:546012

D. Bukulin, "Uloga gangliozida u mehanizmu inzulinske rezistencije", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of biology, Osijek, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:181:546012

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Metadata
TitleUloga gangliozida u mehanizmu inzulinske rezistencije
Title (english)The role of gangliosides in insulin resistance
AuthorDolores Bukulin
MentorValentina Pavić (mentor)
Committee memberValentina Pavić (predsjednik povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of biology
Osijek
Defense date and country2017-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Gangliozidi, kiseli glikosfingolipidi, lipidni su dijelovi stanične membrane koji su poznati kao modulatori transmembranskog signaliziranja. Brojna istraživanja provedena su na ulozi gangliozida u inzulinskoj rezistenciji, patološkom stanju kojeg karakterizira izostanak odgovora stanice ili tkiva na fiziološko lučenje inzulina. Dokazano je kako gangliozidi mogu uzrokovati inzulinsku rezistenciju neposredno, ali i posredno preko citokina TNFα. Neposredna rezistencija kao posljedica povećane ekspresije GM3, najjednostavnijeg gangliozida, podrazumjeva inhibiciju autofosforilacije inzulinskog receptora uslijed čega dolazi do prekida signalnog puta. Posredni utjecaj gangliozida na rezistenciju uključuje djelovanje TNFα, citokina imunosnoga sustava, koji povećava koncentraciju GM3 na staničnoj membrani adipocita. U ovom radu navedeni su mehanizmi i istraživanja koja podupiru navedene primjere i ističu važan utjecaj GM3 kao i TNFα u inzulinskoj rezistenciji, odnosno patologiji šećerne bolesti tipa 2.
Abstract (english)
Gangliosides, acid glycosphingolipids, are lipid components of the cell membrane known as transmembrane signal modulators. Numerous studies have been conducted on the role of gangliosides in insulin resistance, a pathological condition characterized by the absence of the cell or tissue response to physiological secretion of insulin. It has been shown how gangliosides can cause insulin resistance directly, but also indirectly through the cytokine of TNFα. Immediate resistence as a result of increased expression of GM3, the simplest ganglioside, implies the inhibition of insulin receptor autophosphorylation resulting in the signal path interruption. The mediating effect of gangliosides on resistence involves the action of TNFα, a cytokine immune system, which increases the concentration of GM3 on the adipocyte cell membrane. In this paper, the mechanisms and researches that support these examples are listed and they highlight the important influence of GM3 as well as TNFα in insulin resistance, or diabetes mellitus type 2.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:181:546012
Study programmeTitle: Undergraduate University Study Programme in Biology (Bachelor of Science)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-28 12:20:14